I will be periodically updating this page about what we talked about in class. If you have an account on this wiki, I can add you to a specific group which will allow you to add/delete/edit this page. You can also make comments (go down to the bottom of this page)

August 24, 2006 Why Bioprocessing, example of penicillin production (development of liquid/liquid extraction on a large scale), dupont building a plant for 1,3 propanediol using bio-process, monoclonal antibodies, changing paradigm in pharmaceuticals - overview of the course - need for skills in modeling, And how easily one can use and abuse mathematics in modeling Other issues related to mathematics, exams, grading, Philosophy - How I approach my class, courses, The website, The Wiki (Please Read paper on enzyme kinetics - link on Paper on Enzyme and Receptor Kinetics on the Course Website. I also mentioned that we will be reading old issues of the Wall Street Journal and be ready to present a short oral report about the paper you read in class (Make an entry in the wiki)

August 29, 2006 Enzyme kinetics, derivations, plots, calculations - I derived rate expressions using the quasi steady state and the rapid equilibrium assumption - we then discussed techniques to calculate the parameters in the rate expression , and using Lineweaver Burke Plots and other approaches - Please read the sections related to competitive enzyme kinetics in your textbook and we will derive the rate expressions in class - Each of you left with an issue of the Wall Street Journal - please read it and tell the class about any/all stories you may have read related to bioprocessing and such

August 31, 2006 Derivation of competitive enzyme kinetic expressions - we derived the expressions in class - I talked about strategy for solving such problems and asked that you study these carefully and must know how to derive them without any books in front of you - you need to be able to recognize the type of inhibited enzyme kinetics from the slope and the intercept from Lineweaver Burke Plots

September 5, 2006 You should have graph paper, calculators for the class ... and problem set 1 and the papers I want you to read - I will also ask you all to report on the Wall Street Journals you have been reading - Please finish problem 14, problem set 1 that we started in class (calculate the slope and the intercept, determine the nature of the inhibition) - We will be doing other problems from set 1 and from the back of the book

• PartialSolutionProblem14Set1

September 7, 2006 Continuation of problems dealing with enzyme kinetics - we did many problems from problem set 1

September 12, 2006 Enzyme kinetics, problems - We finished problem set 1 - I asked you to carefully study problems 17 and 18 - and answer the questions from Exam 1, Fall 2005 - I started doing problems from the back of the chapter 3 in your textbook, asked you to do as many of those before you come to the next class - I will go over as many of these as time permits - I continue to believe that if you were to spend some time on these problems BEFORE you come to class, you will be able to follow me in class - or ask the questions that will allow you to understand how to do the problems

September 14, 2006 I will talk about what you can expect in Exam I - please come prepared for the next class with your questions

September 19, 2006 We will spend some time on issues/questions related to exam I

September 21, 2006 Exam I (How was the exam? I am glad to see comments - see them below)

September 26, 2006 I discussed the exam (and about plotting and such) (I will try and have it graded by the next class) - we started talking about how cells grow, how to monitor cells in culture and characterizing cell growth - I asked you all to print and bring problem set 2 to class (a reminder - do bring calculators to every class!)

September 28, 2006 I made some additional comments about the exam (after the grading) - We examined growth curves, concept of yield coefficients, equations for the Continuous stirred tank reactor, the concept of a dilution factor - I asked you all to print problem set 2 and come to class

October 3, 2006 We did problems from Problem set 2 - I asked you all to please finish some of the problems I had started but did not finish (MAGIC for example) - I asked you to take a look at problems from the back of the chapter that we will be spending some time next week (after fall break) - I gave each of you atleast one copy of a wall street journal - please read it and post interesting stories (by the end of the semester, I want to see everyone contributing in a meaningful way)

October 5, 2006 Fall Break (No class)

October 10, 2006 Chapter 6 problems - We started many problems, I gave you answers to a few, left you dangling for others - asked you all to come prepared for the next class with answers - in particular the problems involving calculation of X and dX/dT from OUR versus time

October 12, 2006 I had also asked you all to look for a figure in your book which shows how ecoli uses two different carbon sources - do pay attention to what I ask you all to do - We continued with problems from problem set 2 and from the back of the chapter. I reminded all of you to always carefully read the problem statement, determine what is given, what assumptions you can (and cannot make) and clearly work towards the solution

October 17, 2006 We started Chapter 7, short class - Please read the example problems in the chapter.

October 19, 2006 Problems from Chapter 7, I asked you to finish several problems and check the answers against what I gave you, I also asked you to look at the pathway question in problem set II

October 24, 2006 Exam II postponed to Thursday, October 26, 2006 - We will talk about the material for the exam and then continue forward

October 26, 2006 *Exam II*

October 31, 2006 Brief review of Exam II, Design and analysis of Bioreactors, comparing batch versus continuous reactors for biomass production

November 2, 2006 CSTR with recycle, CSTR's in sequence - Please read the example problems in Chapter 9 carefully - and come to class with graph paper (as you always should)

November 7, 2006 Example problems from the textbook - how to calculate X and P from the graphical constructions as shown in the text

November 9, 2006 Problems from the back of the chapter 9 and from problem set 2 that we had not done

November 14, 2006 Continued working on problems from Chapter 9, renewed discussion of graphical construction techniques for multiple reactors

November 16, 2006 We started discussion about topics in Chapter 10, there were some questions about the exam

November 21, 2006 Exam III (Good Luck - As always, read the questions carefully, PLEASE ANSWER ON ONLY ONE SIDE OF THE PAPER

November 23, 2006 Thanksgiving Holiday - Eat, Be Merry, Watch Football

November 28, 2006 Review of Exam III, continuation of concepts in Chapter 10, issues related to mammalian and plant cell culture

November 30, 2006 Overview

December 5, 2006 Last Class - Final presentations, reports

December 7, 2006

December 11, 2006 I may hide from all of you (!) ... Please do not wait till the last day to come to me with questions about the final exam.

December 12, 2006 Scheduled Final Exam, 11:30 to 2:00 PM

• Please post your comments/suggestions about Exam III. If something is not clear, make assumptions, write them down clearly so I know where you are headed and what you want to say -- KrishnanChittur - 20 Nov 2006 - 15:03
• Exam II harder? I thought it was easier ... anyone else comments? -- KrishnanChittur - 31 Oct 2006 - 11:07
• I think Exam II is little harder than Exam I. -- LiQiu - 26 Oct 2006 - 22:25
• Do not forget the questions in this exam - make sure (if you are not already) how to solve ALL the problems correctly ... (and certainly how to generate and interpret plots) -- KrishnanChittur - 29 Sep 2006 - 06:13
• I would say that this was about a 7 also. Problem #1 was a little confusing. I spent most of the test time having to do #3, but did get it done with just enough time to do #4. I did have most of the problems mostly worked out before the exam. -- NicWard - 26 Sep 2006 - 11:03
• OK - points taken - BUT ... I had hoped that you would have worked out most of the problems ahead of time - I am glad to see posts/comments - it always plays to plan (1,2 and 4 should not have taken much time) - We'll talk about it in class ... -- KrishnanChittur - 25 Sep 2006 - 13:32
• I concur with the other students on the time consumption of problem #3. I recall having only 9 minutes to complete problem #4 after wasting over 30min on problem #3. I think that may have costed me some points on the last problem, since I didn't have adequate time to read over the problem statement. I would say 5/10 (average difficulty). -- JonasBoateng - 25 Sep 2006 - 10:13
• I guess I would probably give it about a 7 as well. It did take a while to do the graphing for number three, which had me kind of hurrying through the rest, but in all it wasn't bad. Oh yeah, and Im really peeved at myself for messing up number one. Ironic that the one type of problem I was hoping for will probably be the one to hurt me the most. -- LoriRichter - 24 Sep 2006 - 19:04
• I would give it about a 7 on a scale of ten. I had wish that I had a little more time espically with problem number three. The plotting took most of the time that I had for the test. Other than that I feel that the test was alright. -- JustinGransky - 24 Sep 2006 - 15:13
• How was Exam I? On a scale of 1 to 10 (1 being easy, 10 being tough)? Did you have enough time? -- KrishnanChittur - 22 Sep 2006 - 10:20
• If you add a comment within this box, it will show up like this. -- KrishnanChittur - 23 Aug 2006 - 13:11

-- KrishnanChittur - 19 Oct 2006